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A rare case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation

Xiaofeng Shi, Rong Ba, Haiyan You, Qian Jiang, Jiansong Huang, Jianhua Mao, Lanxiu Han, Shuo Zhang, Qin Zhuang, Xianqiu Yu, Lixia Wang, Yun Wang, Dongya Li, Wei Zhu, Yong Zhang, Yan Zhu, Xiaodong Xi

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 324-329 doi: 10.1007/s11684-017-0558-z

Abstract:

Splenic lymphoma with villous lymphocytes (SLVL) or splenic marginal zone lymphoma with circulatingvillous lymphocytes is rare, and prolymphocytic transformation of SLVL is rarer.In this study, we report a case of B-lymphoproliferative disorder with villous lymphocytes harboringThe abnormal lymphocytes had short coarse villi and round nuclei with prominent nucleoli.In this report, we described an unusual case of B-lymphoproliferative disorder with villous lymphocytes

Keywords： splenic lymphoma with villous lymphocytes     splenic marginal zone lymphoma     transformation     chromosome translocation    

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Development of splenic surgery in China

JIANG Hongchi, ZHAO Xianqi, GAO Yue

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 126-129 doi: 10.1007/s11684-007-0024-4

Abstract: Splenic surgery has enjoyed rapid progress for the past decades in China.practice, many advanced concepts with applicable clinical frameworks have been established, thus making splenicSpleen function is a key issue that generally guides advances in splenic surgery.Now, standard grading for splenic injury and the respective guidelines for clinical management have beenAltogether, splenic surgery is a new and prosperous discipline, and it is a tremendous stage for young

Keywords： function     respective     prosperous discipline     knowledge     indispensable division    

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Advances in immunopathogenesis of adult immune thrombocytopenia

Xinguang Liu, Yu Hou, Jun Peng

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 418-424 doi: 10.1007/s11684-013-0297-8

Abstract:

Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immune-mediated accelerated platelet destruction and/or suppressed platelet production. Although the development of autoantibodies against platelet glycoproteins remains central in the pathophysiology of ITP, several abnormalities involving the cellular mechanisms of immune modulation have been identified, and the pathways behind the immune-mediated destruction of platelets have opened new avenues for the design of specific immunotherapies in an attempt to reduce the platelet destruction. This review is primarily focused on the recent literature with respect to immunopathological mechanisms in patients with ITP.

Keywords： primary immune thrombocytopenia     B lymphocytes     T lymphocytes     antigen-presenting cells     cytokines    

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study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large B-cell lymphoma

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 285-294 doi: 10.1007/s11684-021-0843-8

Abstract: bearing 4-1BB costimulatory molecule, for the treatment of patients with refractory diffuse large B-cell lymphoma

Keywords： CAR-T cell therapy     refractory diffuse large B-cell lymphoma     cytokine release syndrome     dose-limiting    

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Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 699-713 doi: 10.1007/s11684-022-0972-8

Abstract: strong>–50% long-term complete response in relapsed or refractory diffuse large B-cell lymphomamicroenvironments and reprogramming immune cell metabolism as effective therapeutic strategies to prevent lymphoma

Keywords： anti-CD19 chimeric antigen receptor T     immunotherapy     diffuse large B cell lymphoma     tumor microenvironment    

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Tim-3 mRNA expression in peripheral blood lymphocytes from asthmatic patients

Xiaoxia LU, Weikun HU, Shengdao XIONG, Guopeng XU, Fen LAN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 187-190 doi: 10.1007/s11684-009-0033-6

Abstract: cell surface protein T cell Ig and mucin domain-containing molecule-3 (Tim-3) mRNA in peripheral blood lymphocytesThe increased expression of Tim-3 mRNA in peripheral blood lymphocytes might be involved in the development

Keywords： asthma     airway inflammation     peripheral blood lymphocyte     Tim-3    

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Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

Frontiers of Medicine   Pages 889-906 doi: 10.1007/s11684-023-0994-x

Abstract: Primary central nervous system lymphoma (PCNSL) is an uncommon non-Hodgkin’s lymphoma with poor prognosis

Keywords： primary central nervous system lymphoma     whole-genome sequencing     TMSB4X     copy number variation    

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Splenic autotransplantation and oesophageal transection anastomosis in patients with portal hypertension

CHEN Jisheng, HUO Jinshan, ZHANG Hongwei, SHANG Changzhen, CHEN Rufu, ZHANG Jie, Obetien Mapudengo, CHEN Yajin, ZHANG Lei

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 30-35 doi: 10.1007/s11684-007-0006-6

Abstract: In this study, we evaluated the effectiveness of a new treatment strategy: splenic auto-transplantationand oesophageal transection anastomosis on 274 patients from three aspects: clinical observation, splenicSplenic auto transplantation and esophageal transection anastomosis are a safe, effective, and reasonable

Keywords： esophageal transection     oesophageal transection     RCT     dynamic contrast     DCE MRA    

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Primary spinal epidural non-Hodgkin’s lymphoma presented with spinal cord compression syndrome

Chunquan CAI MD, PhD, Qingjiang ZHANG BM, Changhong SHEN MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 499-502 doi: 10.1007/s11684-009-0075-9

Abstract: boy suffered spinal cord compression syndrome caused by primary spinal epidural non-Hodgkin’s lymphomaHistological examination revealed a non-Hodgkin’s B-cell lymphoma.Bone marrow aspiration was negative for lymphoma involvement.

Keywords： non-Hodgkin’     s lymphoma     primary     spinal cord compression syndrome     epidural space    

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extranodal involvement may affect the survival of patients with relapsed or refractory non-Hodgkin lymphoma

Lili Zhou, Ping Li, Shiguang Ye, Xiaochen Tang, Junbang Wang, Jie Liu, Aibin Liang

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 786-791 doi: 10.1007/s11684-020-0751-3

Abstract: anti-CD19 chimeric antigen receptor T (CAR-T) cell immunotherapy for relapsed or refractory non-Hodgkin lymphomaIn a cohort of 32 treated patients, 12 (37.5%) and 8 (25%) patients exhibited soft tissue lymphoma and

Keywords： anti-CD19 chimeric antigen receptor T cell     soft tissue     bone marrow     relapsed or refractory non-Hodgkin lymphoma    

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Expression and bioinformatic analysis of lymphoma-associated novel gene KIAA0372

BAI Xiangyang, TANG Duozhuang, ZHU Tao, SUN Lishi, YAN Lingling, LU Yunping, ZHOU Jianfeng, MA Ding

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 93-98 doi: 10.1007/s11684-007-0018-2

Abstract: The purpose of this study was to explore the differentially expressed genes in lymph-node cells (LNC) of lymphomas and reactive lymph node hyperplasia, and to perform an initial bioinformatic analysis on a novel gene, KIAA0372, which is highly expressed in the LNC of lymphomas. mRNA extracted from LNC of lymphomas and reactive lymph node hyperplasia were respectively marked with biotin and hybridized with Gene Expression Chips, resulting in differentially expressed genes. Initial bioinformatic analysis was then performed on a novel gene named KIAA0372, whose function has not yet been explored. Its structure and genomic location, its product s physical and chemical properties, subcellular localization and functional domains, were also predicted. Further, a systematic evolution analysis was performed on similar proteins from among several species. Using Gene Expression Chips, many differentially expressed genes were uncovered. Efficient bioinformatic analysis has fundamentally determined that KIAA0372 is an extracellular protein which may be involved in TGF-β signaling. Microarray is an efficient and high throughput strategy for detection of differentially expressed genes. And KIAA0372 is thought to be a potential target for tumor research using bioinformatic analysis.

Keywords： bioinformatic analysis     functional     KIAA0372     detection     Microarray    

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thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism in medulloblastoma/PNET and Hodgkin lymphoma

Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 101-107 doi: 10.1007/s11684-020-0752-2

Abstract: protective effect of suppressing TSH with L-thyroxine during RT for medulloblastoma/PNET and Hodgkin lymphoma

Keywords： iatrogenic primary hypothyroidism     late effects of radiotherapy     long-term follow-up     medulloblastoma     Hodgkin lymphoma    

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Therapeutic effects of thalidomide in hematologic disorders: a review

Miao Xu, Yu Hou, Lei Sheng, Jun Peng

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 290-300 doi: 10.1007/s11684-013-0277-z

Abstract: therapeutic effects in hematology, including those on multiple myeloma, Waldenstroem macroglobulinemia, lymphoma, mantle-cell lymphoma, myelodysplastic syndrome, hereditary hemorrhagic telangiectasia, and graft-versus-host

Keywords： thalidomide     multiple myeloma     lymphoma    

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Management of mantle cell leukemia with cardiac involvement leading to cardiogenic shock

Muhammad Furqan,Yamei Chen,Akintunde Akinleye,Judy Sarungbam,Alan Gass,Karen Seiter,Delong Liu

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 254-258 doi: 10.1007/s11684-014-0319-1

Abstract:

Mantle cell lymphoma is an aggressive subtype of B cell non-Hodgkin lymphoma.report of myocardial infiltration by this disease since the appraisal of the term “mantle cell lymphoma

Keywords： mantle cell lymphoma     bendamustine     cardiogenic shock    

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Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 815-826 doi: 10.1007/s11684-021-0891-0

Abstract: Oral drugs such as ibrutinib play an important role in the treatment of mature B-cell lymphoma (BCL)

Keywords： B-cell lymphoma     oral drug     targeted therapy     immunotherapy     COVID-19 pandemic    

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Title Author Date Type Operation

A rare case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation

Xiaofeng Shi, Rong Ba, Haiyan You, Qian Jiang, Jiansong Huang, Jianhua Mao, Lanxiu Han, Shuo Zhang, Qin Zhuang, Xianqiu Yu, Lixia Wang, Yun Wang, Dongya Li, Wei Zhu, Yong Zhang, Yan Zhu, Xiaodong Xi

Journal Article

Development of splenic surgery in China

JIANG Hongchi, ZHAO Xianqi, GAO Yue

Journal Article

Advances in immunopathogenesis of adult immune thrombocytopenia

Xinguang Liu, Yu Hou, Jun Peng

Journal Article

study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large B-cell lymphoma

Journal Article

Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Journal Article

Tim-3 mRNA expression in peripheral blood lymphocytes from asthmatic patients

Xiaoxia LU, Weikun HU, Shengdao XIONG, Guopeng XU, Fen LAN

Journal Article

Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

Journal Article

Splenic autotransplantation and oesophageal transection anastomosis in patients with portal hypertension

CHEN Jisheng, HUO Jinshan, ZHANG Hongwei, SHANG Changzhen, CHEN Rufu, ZHANG Jie, Obetien Mapudengo, CHEN Yajin, ZHANG Lei

Journal Article

Primary spinal epidural non-Hodgkin’s lymphoma presented with spinal cord compression syndrome

Chunquan CAI MD, PhD, Qingjiang ZHANG BM, Changhong SHEN MD, PhD,

Journal Article

extranodal involvement may affect the survival of patients with relapsed or refractory non-Hodgkin lymphoma

Lili Zhou, Ping Li, Shiguang Ye, Xiaochen Tang, Junbang Wang, Jie Liu, Aibin Liang

Journal Article

Expression and bioinformatic analysis of lymphoma-associated novel gene KIAA0372

BAI Xiangyang, TANG Duozhuang, ZHU Tao, SUN Lishi, YAN Lingling, LU Yunping, ZHOU Jianfeng, MA Ding

Journal Article

thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism in medulloblastoma/PNET and Hodgkin lymphoma

Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani

Journal Article

Therapeutic effects of thalidomide in hematologic disorders: a review

Miao Xu, Yu Hou, Lei Sheng, Jun Peng

Journal Article

Management of mantle cell leukemia with cardiac involvement leading to cardiogenic shock

Muhammad Furqan,Yamei Chen,Akintunde Akinleye,Judy Sarungbam,Alan Gass,Karen Seiter,Delong Liu

Journal Article

Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Journal Article